chondroitin sulfate clinical studies

2022-02-10 09:22:08

【indications for efficacy】lipid-lowering drugs. it is mainly used for the treatment of hyperlipidemia. clinical applications include:

1. chondroitin sulfate as a health food or health care drug has long been used in the prevention and treatment of coronary heart disease, angina, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, without obvious toxic side effects, which can significantly reduce the incidence and mortality of patients with coronary heart disease. long-term clinical application has found that lipids such as fat deposited on arterial and venous walls can be effectively removed or reduced, which can significantly reduce plasma cholesterol and thus prevent the formation of atherosclerosis.

2. chondroitin sulfate is used to treat neuralgia, neuropathic migraine, arthralgia, arthritis and shoulder blade joint pain, pain after abdominal surgery, etc. 

3. prevent and treat hearing impairment caused by streptomycin, hearing difficulties caused by various noises, tinnitus, etc., with remarkable effects.

4. it has an adjuvant therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcers.

5. it was reported in 2010 that chondroitin in shark cartilage has anti-tumor effects.

6. in addition, chondroitin sulfate is also used in eye drops, cosmetics and healing agents for traumatic wounds. 

【CHEMICAL COMPOSITION】 ACIDIC MUCOPOLYSACCHARIDES OBTAINED FROM CARTILAGE TISSUES SUCH AS THROAT BONE, NASAL BONE, AND TRACHEA OF PIGS. THE AMINOHEXOSE CONTAINED IN THIS PRODUCT IS CALCULATED BY GLUCOSAMINE (C6H13O5N), WHICH IS NOT LESS THAN 24.0% OF THE INDICATED AMOUNT OF CHONDROITIN SULFATE. [6] 

【PHARMACOLOGICAL EFFECT】CHONDROITIN SULFATE IS WIDELY PRESENT IN HUMAN AND ANIMAL CARTILAGE TISSUES. ITS MEDICINAL PREPARATIONS MAINLY CONTAIN TWO ISOMERS OF CHONDROITIN SULFATE A AND CHONDROITIN SULFATE C, AND THE CONTENT OF CHONDROITIN SULFATE IN CARTILAGE OF DIFFERENT SPECIES, AGES AND OTHER ANIMALS IS DIFFERENT. ITS PHARMACOLOGICAL EFFECTS ARE MANIFESTED BY:

1. chondroitin sulfate can remove lipids and lipoproteins from the blood in the body, remove cholesterol from blood vessels around the heart, prevent and treat atherosclerosis, and increase the conversion rate of lipids and fatty acids in cells. 

2. chondroitin sulfate can effectively prevent and treat coronary heart disease. it has anti-atherosclerotic and anti-atherogenic plaque formation effects on experimental arteriosclerosis models, increases coronary artery sub-techniques or collateral circulation of atherosclerosis, and can accelerate the healing, regeneration and repair of myocardial necrosis or degeneration caused by experimental coronary arteriosclerosis or embolism.  

3. It can increase the biosynthesis of the cell's messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) and promote cell metabolism. 

4. Low anticoagulant activity. Chondroitin sulfate has a moderate anticoagulant effect, and each lmg of chondroitin sulfate A corresponds to the anticoagulant activity of 0.45U of heparin. This anticoagulant activity does not depend on antithrombin III, which can exert anticoagulant activity through the fibrinogen system. 

5. chondroitin sulfate also has anti-inflammatory, accelerated wound healing and anti-tumor effects. 

【adverse reactions】 individuals have chest tightness, nausea, and a small amount of bleeding from the gums.