Heparin is an anionic sulfated aminoglucan. It is a heterogeneous substance with an average molecular weight of 12 000 and exists on the surface of many main cells. Commercial heparin sodium was extracted from pig intestines or cattle lungs. Heparin is composed of non branched low sugar chains with different lengths. D-glucosamine and D-glucuronic acid (or l-iduronic acid) are linked by glycosidic chains to form the basic disaccharide repeat of heparin chain. There are many substitutions in the repeated disaccharide sequence. It includes: R1: H or - oso3 group, R2: SO3 or - coch3 group, so that a few disaccharides form pentose sequence. The molecular weight of heparin is 3-30kda (most chains are 13-15kda).

Although the metabolism of heparin is complex, it may, for the purpose of choosing a protamine dose, be assumed to have a half-life of about 1/2 hour after intravenous injection. Administration of protamine sulfate can cause severe hypotensive and anaphylactoid reactions.

What are side effects of heparin? Heparin side effects bruising more easily. bleeding that takes longer to stop. irritation, pain, redness, or sores at the injection site. allergic reactions, such as hives, chills, and fever. increased liver enzymes on liver function test results. Related tags： Previous page： How do you use Heparin Sodium Topical Solution? Next page： Does heparin affect blood pressure?

Heparin combined with the following drugs can increase the risk of bleeding: coumarin and its derivatives, aspirin and non steroidal anti-inflammatory analgesics, dipyridamole, dextran, adrenocortical hormone, adrenocorticotropic hormone, tissue plasminogen activator, urokinase, streptokinase, etc.