Cirrhosis is the result of years of chronic liver disease (Cld). CLD is usually silent. It slowly changes the liver by reorganizing the liver's structure, combining the wound healing process (such as remodeling and fibrosis) with the reduction of functional parenchymal masses, and ultimately leading to liver cirrhosis. Cirrhosis of the liver is also silent for many years, the entire organism (skin, brain, kidney, gastrointestinal tract, immune system, bone marrow, heart, etc.). Changes and adaptation of sick liver. These changes may foreshadow and prompt the patient's final showdown? That is, an acute decompensation event. Microflora, including bacteria (bacteria), fungi (fungi) and viruses (virions), are also believed to change during the onset and development of liver cirrhosis. Several factors seem to affect the microflora, including the etiology of liver disease, such as alcohol and diet (for non-alcoholic fatty liver disease [NAFLD]). Chronic cholestasis mainly reduces bile flow, causes cholestasis, impairs intestinal hepatic circulation, and mainly affects the microflora. With the progress of chronic obstructive pulmonary disease, changes in microflora (biological disorders) continue and further aggravate, possibly due to changes in intestinal motility, permeability, lymphatic and blood cavity barrier function, portal hypertension, and immune system . However, the role of microflora seems to play a key role in patients with decompensated cirrhosis, because many decompensated events are related to microbes or their interaction with the host.
In order to describe the role of microflora in liver cirrhosis and its role in decompensation, the author introduces acute decompensation (AD) and its most severe form, acute chronic liver failure (ACLF). AD defines the acute development of ascites, hepatic encephalopathy, gastrointestinal bleeding, or bacterial infection, or any combination of these diseases. AD is a sudden and rapid deterioration of health, which is related to the dysfunction of the liver and extrahepatic organs, especially the kidneys and brain. The most severe form of AD is called ACLF, and its 28-day mortality rate is extremely high, close to 40%.
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