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chondroitin sulfate function and use
2022-02-04 14:04:59

1. the main application path in medicine is as a drug for the treatment of joint diseases, which is used in conjunction with glucosamine, which has the effect of relieving pain and promoting cartilage regeneration, and can fundamentally improve joint problems.


provides a cushioning action to ease the impact and friction during movement, sucking moisture into proteoglycan molecules, thickening cartilage and increasing the amount of synovial fluid in the joints. one of the important functions of chondroitin is to act as a transport pipe to transport important oxygen supplies and nutrients to the joints, helping to remove waste products from the joints while removing carbon dioxide and waste products. since articular cartilage has no blood supply, all oxygenation, nourishment and lubrication come from synovial fluid.


2. chondroitin sulfate has a protective effect on corneal collagen fibers, which can promote the growth of fibers in the matrix, enhance permeability, improve blood circulation, accelerate metabolism, promote the absorption of osmotic fluid and the elimination of inflammation; its polyanionics have strong water retention, can improve the water metabolism of corneal tissue, have a strong affinity for the cornea, and can form a breathable water retention film on the surface of the cornea to improve the symptoms of eye dryness. by promoting the production of matrix, it provides a framework for cell migration, which is conducive to the migration of corneal epithelial cells, thereby promoting the healing of corneal trauma, the absorption of exudate and the elimination of inflammation.


3. THROUGH HIGH-TECH DEEP PROCESSING, IT CAN TREAT NEUROTIC HEADACHES, TRIGEMINAL NEURALGIA, CORONARY HEART DISEASE, ANGINA, MYOCARDIAL HYPOXIA, CARDIOVASCULAR AND CEREBROVASCULAR DISEASES, ARTHRALGIA, ATHEROSCLEROSIS AND HEPATITIS, AMONG WHICH CS ALSO HAS ANTICOAGULANT AND ANTITHROMBOTIC EFFECTS, AND CAN ALSO BE USED FOR ADJUVANT THERAPY OF HEARING IMPAIRMENT AND LIVER FUNCTION IMPAIRED CAUSED BY STREPTOMYCIN AND ADJUVANT TREATMENT OF HYPERLIPIDEMIA.


4. it can be used as an additive in health care products and foods, and has the effect of enhancing human physique and resistance to germs, beauty, anti-aging and so on. improves hearing and dry skin. in the body, it can inhibit the absorption of lipids and glucose by the small intestine to achieve a slimming effect.


folding pharmacological action


CS IS WIDELY PRESENT IN HUMAN AND ANIMAL CARTILAGE TISSUES. ITS MEDICINAL PREPARATIONS MAINLY CONTAIN TWO ISOMERS OF CHONDROITIN SULFATE A AND CHONDROITIN SULFATE C, AND THE CONTENT OF CHONDROITIN SULFATE IN CARTILAGE OF DIFFERENT SPECIES, AGES AND OTHER ANIMALS IS DIFFERENT. ITS PHARMACOLOGICAL EFFECTS ARE MANIFESTED BY:


1. CS CAN REMOVE LIPIDS AND LIPOPROTEINS FROM THE BLOOD IN THE BODY, REMOVE CHOLESTEROL FROM BLOOD VESSELS AROUND THE HEART, PREVENT ATHEROSCLEROSIS, AND INCREASE THE CONVERSION RATE OF LIPIDS AND FATTY ACIDS IN CELLS.


2. CS CAN EFFECTIVELY PREVENT AND TREAT CORONARY HEART DISEASE. IT HAS ANTI-ATHEROSCLEROTIC AND ANTI-ATHEROGENIC PLAQUE FORMATION EFFECT ON EXPERIMENTAL ARTERIOSCLEROSIS MODELS; INCREASES CORONARY ARTERY SUB-ARTERY OR COLLATERAL CIRCULATION FOR ATHEROSCLEROSIS AND ACCELERATES HEALING, REGENERATION, AND REPAIR OF MYOCARDIAL NECROSIS OR DEGENERATION CAUSED BY EXPERIMENTAL CORONARY ARTERY SCLEROSIS OR EMBOLISM.


3. It can increase the biosynthesis of cellular messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) and has the effect of promoting cell metabolism.


4. Low anticoagulant activity. Chondroitin sulfate has a moderate anticoagulant effect, and each lmg of chondroitin sulfate A corresponds to the anticoagulant activity of 0.45U of heparin. This anticoagulant activity does not depend on antithrombin III, which can exert anticoagulant activity through the fibrinogen system.


5. chondroitin sulfate also has anti-inflammatory, accelerated wound healing and anti-tumor effects.

  folding for clinical application

long-term clinical application has found that lipids such as fat deposited on arterial and venous walls can be effectively removed or reduced, which can significantly reduce plasma cholesterol and thus prevent the formation of atherosclerosis.

chondroitin sulfate is used to treat neuralgia, neuropathic migraines, arthralgia, arthritis, and shoulder blade joint pain, pain after abdominal surgery, etc.

the prevention and treatment of hearing impairment caused by streptomycin, hearing difficulties caused by various noises, tinnitus, etc., the effect is remarkable.

it has an adjuvant therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcers.

chondroitin in shark cartilage has an anti-tumor effect. in addition, chondroitin sulfate is also used in cosmetics and healing agents for traumatic wounds. chondroitin sulfate is an acidic mucopolysaccharide, one of the important components in the eye tissue, with the ability to promote corneal water metabolism and improvement, suitable for eye fatigue, dry eye.


  improves bone quality

by increasing the supply of chondroitin sulfate, the body's own regulatory mechanism is inhibited, bone hardening is reduced, and the volume of compact and flexible bones is reduced by 10% compared with fragile bones, and the strength is greatly enhanced. in particular, the facial contour is not easily deformed or the expansion is intensified, and the adhesion of the tissue is improved. contour bone process shrinking trend, return to youthful state.

it is important to also take chondroitin when taking glucosamine, as chondroitin promotes the penetration of glucosamine into the joints. multiple studies have shown, including one published in the new england journal of medicine, that a combination of glucosamine and chondroitin is more effective in protecting, reversing damage and promoting the repair of joint cartilage and membranous bone.


  other benefits of chondroitin:

inhibits enzymes that destroy cartilage (e.g., collagenase, elastase, and histinases) so that cartilage does not break down or dissolve

  IT CAN START FROM THE ROOT OF THE PROBLEM AND INHIBIT THE ACTIVITY OF COX-2 TO STOP JOINT INFLAMMATION.


  clinical studies

 【indications for efficacy】 


lipid-lowering drugs. it is mainly used for the treatment of hyperlipidemia. its clinical applications include:


1. chondroitin sulfate as a health food or health care drug has long been used in the prevention and treatment of coronary heart disease, angina, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, without obvious toxic side effects, can significantly reduce the incidence and mortality of patients with coronary heart disease.


2. chondroitin sulfate is used to treat neuralgia, neuropathic migraine, arthralgia, arthritis and shoulder blade joint pain, pain after abdominal surgery, etc.


3. prevention and treatment of hearing impairment caused by streptomycin, hearing difficulties caused by various noises, tinnitus, etc., with remarkable effects.


4. it has an adjuvant therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcers.


5. chondroitin sulfate is also used in cosmetics and healing agents for traumatic wounds.


6. chondroitin sulfate is also used in eye drops.


 【chemical composition】 


ACIDIC MUCOPOLYSACCHARIDES OBTAINED FROM CARTILAGE TISSUES SUCH AS THROAT BONE, NASAL BONE, AND TRACHEA IN PIGS. THE AMINOHEXOSE CONTAINED IN THIS PRODUCT IS CALCULATED BY GLUCOSAMINE (C6H13O5N), WHICH IS NOT LESS THAN 24.0% OF THE INDICATED AMOUNT OF CHONDROITIN SULFATE.


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