Pharmacological effects and indications of Nadroparin Calcium

2021-07-15 11:14:43

Nadroparin calcium is a new type of antithrombotic drug, obtained by depolymerizing heparin extracted from pig intestinal mucosa, with an average molecular weight of 4500 Daltons. In vitro experiments show that, compared with heparin, low molecular weight heparin calcium has obvious anti-Xa activity, but only has a slight anticoagulant activity. The bleeding risk is much lower than heparin, and it has almost no effect on platelets. Subcutaneous injection has high bioavailability, long half-life and outstanding antithrombotic effect.

Nadroparin calcium is a low-molecular-weight heparin preparation, which can make the ratio of anticoagulant factor Ⅹa and Ⅱa activity greater than 4, thereby exerting a strong antithrombotic function and a certain thrombolytic effect. There was no significant change in the total coagulation index at the recommended dose, and the platelet aggregation time and the binding to fibrinogen were also unchanged. Although low molecular weight heparin (LMWH) is suitable for all heparin fragments with a molecular weight of less than 8000 Da, the effect of each fragment still depends on the molecular weight. An in vitro study comparing nadroparin calcium (molecular weight 4000～6000 Da) and unisolated heparin showed that the inhibitory effect of nadroparin calcium on thrombin was reduced by approximately 5 times. In vivo studies have also shown that subcutaneous application of heparin, the activated partial thromboplastin time (APTT) is significantly longer than subcutaneous application of nadroparin calcium.

Nadroparin calcium indications:

1. In surgical operations, it is used in the case of moderate or high risk of venous thrombosis to prevent venous thromboembolic diseases.

2. Treatment of deep vein thrombosis that has formed.

3. Combined with aspirin for the treatment of unstable angina and non-Q-wave myocardial infarction in the acute phase.

4. Prevent blood clot formation during extracorporeal circulation during hemodialysis.